Ketoconazole interacts with 14-α-sterol demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol.5,11 This results in inhibition of ergosterol synthesis and increased fungal cellular permeability due to reduced amounts of ergosterol present in the fungal cell membrane
Fungal skin infection
KETCOTAS belongs to a group of medicines called antifungals. It is used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, thrush and ringworm.